| Smooth Stone Chip | 1 | | | Junk |
| Smotts' Chest | 1 | | | Quest |
| Snapjaw Crocolisk Skin | 1 | | | Quest |
| Snapped Spider Limb | 1 | | | Junk |
| Snapshot of Gammerita | 1 | | | Quest |
| Snellig's Snuffbox | 1 | | | Quest |
| Snickerfang Jowl | 1 | 1 | | Quest |
| Snowman Kit | 1 | | | Junk |
| Snuff | 1 | | | Quest |
| Snufflenose Command Stick | 1 | | | Quest |
| Snufflenose Owner's Manual | 1 | | | Quest |
| Sodium Nitrate | 1 | | | Quest |
| Soft Bushy Tail | 1 | | | Junk |
| Soft Patch of Fur | 1 | | | Junk |
| Soft-shelled Clam | 1 | | | Key |
| Soft-shelled Clam Meat | 1 | | | Quest |
| Solenor's Head | 1 | | | Quest |
| Solid Crystal Leg Shaft | 1 | | | Quest |
| Solomon's Plea to Bolvar | 1 | | | Quest |
| Solomon's Plea to Darkshire | 1 | | | Quest |
| Solomon's Plea to Westfall | 1 | | | Quest |
| Somatic Intensifier | 1 | | | Quest |
| Some Rune | 1 | | | Quest |
| Sooty Parchment | 1 | | | Quest |
| Soran'ruk Fragment | 1 | | | Quest |
| Soul Ashes of the Banished | 1 | | | Quest |
| Soul Gem | 1 | | | Junk |
| Soul Gem | 1 | | | Quest |
| Soul Stained Pike | 1 | | | Quest |
| Soulbound Keepsake | 1 | | | Quest |
| Soulbound Keepsake | 1 | | | Quest |
| Southsea Pirate Hat | 1 | | | Quest |
| Southsea Treasure | 1 | | | Quest |
| Southshore Stout | 1 | | | Consumable |
| Sparklematic-Wrapped Box | 1 | | | Junk |
| Sparkly Necklace | 1 | | | Junk |
| Speck of Dream Dust | 1 | | | Quest |
| Speckled Shell Fragment | 1 | | | Junk |
| Spectral Comb | 1 | | | Quest |
| Spells of Shadow | 1 | | | Quest |