| Spider Palp | 1 | | | Junk |
| Spined Bat Wing | 1 | | | Junk |
| Spire Spider Egg | 1 | | | Quest |
| Spirit of Silverpine Charts | 1 | | | Quest |
| Spirit of Silverpine Log | 1 | | | Quest |
| Splintered Log | 1 | | | Quest |
| Splintered Tusk | 1 | | | Junk |
| Split Bone Necklace | 1 | | | Quest |
| Spool of Light Chartreuse Silk Thread | 1 | | | Quest |
| Spotted Hyena Pelt | 1 | | | Quest |
| Spotted Sunfish | 1 | | | Quest |
| Spraggle's Canteen | 1 | | | Quest |
| Spraggle's Canteen | 1 | | | Quest |
| Spy's Report | 1 | | | Quest |
| Squire's Boots | 1 | | Feet | Miscellaneous |
| Squire's Pants | 1 | 1 | Legs | Cloth |
| Squire's Pants | 1 | 1 | Legs | Cloth |
| Squire's Shirt | 1 | | Shirt | Miscellaneous |
| Squire's Shirt | 1 | | Shirt | Miscellaneous |
| Squirrel Nut | 1 | | | Consumable |
| Squirrel Token | 1 | | | Quest |
| Squirrel Token | 1 | | | Quest |
| Squishy Basilisk Eye | 1 | | | Junk |
| Stable Ectoplasm | 1 | | | Quest |
| Stack of Cards | 1 | | | Consumable |
| Staff Head of Atiesh | 1 | | | Quest |
| Staff of Command | 1 | | | Quest |
| Staff of Prehistoria | 1 | | | Quest |
| Stalker Claws | 1 | | | Quest |
| Stalker's Harness | 1 | | Shirt | Miscellaneous |
| Stalker's Pants | 1 | 1 | Legs | Cloth |
| Stalker's Shoes | 1 | 1 | Feet | Miscellaneous |
| Star of Xil'yeh | 1 | 1 | Held In Off-hand | Miscellaneous |
| Star of Xil'yeh | 1 | | | Quest |
| Starbreeze Village Relic | 1 | | | Quest |
| Stave of Equinex | 1 | | | Quest |
| Steamsaw | 1 | | | Quest |
| Steel Arrowhead | 1 | | | Junk |
| Steelgrill's Tools | 1 | | | Quest |
| Steelsnap's Rib | 1 | | | Quest |