| Silvermane Stalker Flank | 1 | | | Quest |
| Silverwing Talisman of Merit | 1 | | | Quest |
| Silvery Claws | 1 | | | Quest |
| Simone's Head | 1 | | | Quest |
| Simple Letter | 1 | | | Quest |
| Simple Memorandum | 1 | | | Quest |
| Simple Note | 1 | | | Quest |
| Simple Parchment | 1 | | | Quest |
| Simple Parchment | 1 | | | Quest |
| Simple Rune | 1 | | | Quest |
| Simple Scroll | 1 | | | Consumable |
| Simple Sigil | 1 | | | Quest |
| Simple Tablet | 1 | | | Quest |
| Singed Corestone | 1 | | | Junk |
| Singed Scale | 1 | | | Consumable |
| Singed Scroll Fragment | 1 | | | Quest |
| Singing Blue Crystal | 1 | | | Quest |
| Singing Crystal Shard | 1 | | | Quest |
| Six of Beasts | 1 | | | Junk |
| Six of Elementals | 1 | | | Junk |
| Six of Portals | 1 | | | Junk |
| Six of Warlords | 1 | | | Junk |
| Sixth Mosh'aru Tablet | 1 | | | Quest |
| Skeletal Fragments | 1 | | | Quest |
| Skeleton Finger | 1 | | | Quest |
| Skeleton Key | 1 | | | Key |
| Skeleton Key Mold | 1 | | | Quest |
| Skin of Shadow | 1 | | | Quest |
| Skin of Sweet Rum | 1 | | | Quest |
| Skin of the Great Sandworm | 1 | | | Quest |
| Skittering Blood | 1 | | | Quest |
| Skull Key | 1 | | | Consumable |
| Skull of Horgus | 1 | | | Quest |
| Skull of the Coldbringer | 1 | | | Quest |
| Skullsplitter Coin | 1 | | | Quest |
| Skullsplitter Fetish | 1 | | | Quest |
| Skullsplitter Tusk | 1 | | | Quest |
| Skylord Plume | 1 | | | Quest |
| Slab of Carrion Worm Meat | 1 | | | Quest |
| Slagtree's Lost Tools | 1 | | | Quest |