| Security DELTA Data Access Card | 1 | | | Junk |
| Seed of Life | 1 | | | Quest |
| Seed Voucher | 1 | | | Quest |
| Seeping Gizzard | 1 | | | Junk |
| Senir's Report | 1 | | | Quest |
| Sentinel Advanced Care Package | 1 | | | Consumable |
| Sentinel Basic Care Package | 1 | | | Consumable |
| Sentinel Standard Care Package | 1 | | | Consumable |
| Sentinel's Card | 1 | | | Consumable |
| Serena's Head | 1 | | | Quest |
| Serpentbloom | 1 | | | Quest |
| Serrated Petal | 1 | | | Junk |
| Sethir's Journal | 1 | 1 | | Quest |
| Seven of Beasts | 1 | | | Junk |
| Seven of Elementals | 1 | | | Junk |
| Seven of Portals | 1 | | | Junk |
| Seven of Warlords | 1 | | | Junk |
| Severed Bat Claw | 1 | | | Junk |
| Severed Horn of the Defiler | 1 | | | Quest |
| Severed Pincer | 1 | | | Junk |
| Severed Talon | 1 | | | Junk |
| Sevren's Orders | 1 | | | Quest |
| Sha'ni's Nose-Ring | 1 | | | Quest |
| Shabby Knot | 1 | | | Junk |
| Shackle Key | 1 | | | Key |
| Shackle Key | 1 | | | Quest |
| Shadow Lord Fel'dan's Head | 1 | | | Quest |
| Shadow Panther Heart | 1 | | | Quest |
| Shadow Sword | 1 | 1 | Main Hand | Sword |
| Shadowforge Key | 1 | | | Key |
| Shadowglen Gift Voucher | 1 | | | Quest |
| Shadowhide Pendant | 1 | | | Quest |
| Shadowmaw Claw | 1 | | | Quest |
| Shadowshard Fragment | 1 | | | Quest |
| Shadowstalker Scalp | 1 | | | Quest |
| Shadowy Potion | 1 | | | Quest |
| Shadowy Potion OLD | 1 | | | Quest |
| Shadra's Venom | 1 | | | Quest |
| Shaky's Payment | 1 | | | Quest |
| Shane Test (DELETE ME) | 1 | 1 | Head | Consumable |