| Sayge's Fortune #9 | 1 | | | Junk |
| Scaber Stalk | 1 | | | Quest |
| Scale of Old Murk-Eye | 1 | | | Quest |
| Scallop Shell | 1 | | | Junk |
| Scarab Bag | 1 | | | Junk |
| Scarab Coffer Key | 1 | | | Key |
| Scarlet Armband | 1 | | | Quest |
| Scarlet Crusade Documents | 1 | | | Quest |
| Scarlet Insignia Ring | 1 | | | Quest |
| Scavenger Paw | 1 | | | Quest |
| Scepter of Beckoning: Fire | 1 | | | Junk |
| Scepter of Beckoning: Stone | 1 | | | Junk |
| Scepter of Beckoning: Thunder | 1 | | | Junk |
| Scepter of Beckoning: Water | 1 | | | Junk |
| Scepter of Celebras | 1 | | | Quest |
| Scepter of Vectus | 1 | | | Quest |
| Sceptre of Light | 1 | | | Quest |
| Scooby Snack | 1 | 1 | | Consumable |
| Scorched Ectoplasm | 1 | | | Quest |
| Scorched Spider Fang | 1 | | | Quest |
| Scorpashi Venom | 1 | | | Quest |
| Scorpid Worker Tail | 1 | | | Quest |
| Scorpok Pincer | 1 | 1 | | Quest |
| Scourge Banner | 1 | | | Quest |
| Scourge Data | 1 | | | Quest |
| Scrap Metal | 1 | | | Quest |
| Scrap of Paper | 1 | | | Quest |
| Scratching Stick | 1 | | | Junk |
| Scrawled Parchment | 1 | | | Quest |
| Scrimshank's Surveying Gear | 1 | | | Quest |
| Scroll of Celebras | 1 | | | Quest |
| Scroll of Messaging | 1 | | | Quest |
| Scroll: Create Crest of Beckoning | 1 | | | Junk |
| Scroll: Create Crest of Beckoning | 1 | | | Junk |
| Scroll: Create Crest of Beckoning | 1 | | | Junk |
| Scroll: Create Crest of Beckoning | 1 | | | Junk |
| Scroll: Create Scepter of Beckoning | 1 | | | Junk |
| Scroll: Create Scepter of Beckoning | 1 | | | Junk |
| Scroll: Create Scepter of Beckoning | 1 | | | Junk |
| Scroll: Create Scepter of Beckoning | 1 | | | Junk |