| Durability Staff | 1 | | Two-Hand | Staff |
| Durability Sword | 1 | | One-Hand | Sword |
| Durnan's Scalding Mornbrew | 1 | | | Quest |
| Durotar Tiger Fur | 1 | | | Quest |
| Duskbat Pelt | 1 | | | Quest |
| Duskbat Wing | 1 | | | Quest |
| Dusky Crab Cakes | 1 | | | Quest |
| Dust Devil Debris | 1 | | | Quest |
| Dwarven Homebrew | 1 | | | Consumable |
| Dwarven Tinder | 1 | | | Quest |
| E.C.A.C. | 1 | | | Consumable |
| Eagle Eye | 1 | | | Junk |
| Ear of Balgaras | 1 | | | Quest |
| Earth Sapta | 1 | | | Consumable |
| Eau de Mixilpixil | 1 | 1 | | Consumable |
| Ebonlocke's Response to Solomon | 1 | | | Quest |
| Echeyakee's Hide | 1 | | | Quest |
| Ectoplasmic Distiller | 1 | | | Quest |
| Ectoplasmic Resonator | 1 | | | Quest |
| Edana's Dark Heart | 1 | | | Quest |
| Egalin's Grimoire | 1 | | | Quest |
| Egan's Blaster | 1 | | Ranged | Quest |
| Egan's Blaster | 1 | | Ranged | Quest |
| Egg Crate | 1 | | | Quest |
| Eggscilloscope | 1 | | | Key |
| Eggscilloscope Prototype | 1 | | | Quest |
| Eight of Beasts | 1 | | | Junk |
| Eight of Elementals | 1 | | | Junk |
| Eight of Portals | 1 | | | Junk |
| Eight of Warlords | 1 | | | Junk |
| Elaborate Parchment | 1 | | | Quest |
| Eldarathian Tome of Summoning Vol. 1 | 1 | | | Consumable |
| Elder Crocolisk Skin | 1 | | | Quest |
| Elder Raptor Feathers | 1 | | | Junk |
| Elder's Moonstone | 1 | | | Consumable |
| Elderberry Pie | 1 | 1 | | Consumable |
| Elders' Square Postbox Key | 1 | | | Key |
| Eldritch Shackles | 1 | | | Quest |
| Electropeller | 1 | | | Quest |
| Elegant Letter | 1 | | | Quest |